hERG/HEK293
CBP75048
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| I. Background | |
| hERG（human Ether-à-go-go-Related Gene）即 KCNH2 基因，编码 Kv11.1 钾通道，是心肌细胞复极化电流 (IKr) 的关键通道。 | |
| II. Introduction | |
| Host Cell: | HEK293 |
| Expressed gene: | hERG |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
DMEM + 10% FBS+100 μg/ml Zeocin |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | Embryonic kidney |
| Disease: | Normal |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| IV. Representative Data | |
Figure 1. Inhibition of hERG current by Cisapride.
Figure 2. raw current traces responding to vehicle and six doses of compound.
